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Article Dans Une Revue Physical Review Letters Année : 2009

Inferring maps of forces inside cell membrane microdomains

Résumé

Mapping of the forces on biomolecules in cell membranes has spurred the development of effective labels, e.g., organic fluorophores and nanoparticles, to track trajectories of single biomolecules. Standard methods use particular statistics, namely the mean square displacement, to analyze the underlying dynamics. Here, we introduce general inference methods to fully exploit information in the experimental trajectories, providing sharp estimates of the forces and the diffusion coefficients in membrane microdomains. Rapid and reliable convergence of the inference scheme is demonstrated on trajectories generated numerically. The method is then applied to infer forces and potentials acting on the receptor of the toxin labeled by lanthanide-ion nanoparticles. Our scheme is applicable to any labeled biomolecule and results show its general relevance for membrane compartmentation. Cop. 2009 The American Physical Society.
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Dates et versions

hal-00811680 , version 1 (18-04-2014)

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J.-B. Masson, Didier Casanova, Silvan Türkcan, G. Voisinne, Michel Popoff, et al.. Inferring maps of forces inside cell membrane microdomains. Physical Review Letters, 2009, 102 (4), pp.48103. ⟨10.1103/PhysRevLett.102.048103⟩. ⟨hal-00811680⟩
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