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Modeling the effects of lipid peroxidation during ferroptosis on membrane properties

Abstract : Ferroptosis is a form of regulated cell death characterized by the accumulation of lipid hydroperoxides. There has been significant research on the pathways leading to the accumulation of oxidized lipids, but the downstream effects and how lipid peroxides cause cell death during ferroptosis remain a major puzzle. We evaluated key features of ferroptosis in newly developed molecular dynamics models of lipid membranes to investigate the biophysical consequences of lipid peroxidation, and generated hypotheses about how lipid peroxides contribute to cell death during ferroptosis.
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https://hal.archives-ouvertes.fr/hal-03366986
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Submitted on : Wednesday, October 6, 2021 - 5:38:23 AM
Last modification on : Tuesday, January 4, 2022 - 4:58:36 AM
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Eran Agmon, Jérôme Solon, Patricia Bassereau, Brent R Stockwell. Modeling the effects of lipid peroxidation during ferroptosis on membrane properties. Scientific Reports, Nature Publishing Group, 2018, 8 (1), ⟨10.1038/s41598-018-23408-0⟩. ⟨hal-03366986⟩

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