Central nervous system Duchenne muscular dystrophy Humans Thérapie génique Cell culture model Glucocorticoid-receptor Oligodendrocytes Therapy DM1 Lc3 BIOLOGIE MOLECULAIRE Mice Myotonic Dystrophy Myelin Neuron Heart failure RNA interference Glial cells Heart Acetylcholinesterase deficiency Myotonic dystrophy Expression RNA biology DMSXL mice Dystrophie Myotonique Cardiac muscle CRISPR/Cas9 Myostatin Transgenic mouse model Autophagy CTG repeat contractions Intermediate filament Dystrophin DMPK Centronuclear myopathy Transcriptomics Myotonic Dystrophy type 1 Transgenic mouse Myotonic dystrophy type 1 CTG repeat instability CMS Mouse models Antisense oligonucleotides GSK3␤ PacBio Motoneuron Myotonic dystrophy mouse models Dilated cardiomyopathy CONGENITAL MYATHENIC SYNDROME Mouse model Cell penetrating peptide KNOCKOUT MICE Gene Therapy CTG repeats Trinucleotide Repeat Expansion AAV Glutamate Animals Gene therapy RNA splicing Exercice Trinucleotide repeat expansion Glucocorticoids GABA Brain dysfunction Cell model Desmin In vivo MBNL Exercise Acute coronary syndrome Knockout Hypoxia Aging Gene editing Cytoskeleton Myotonic Dystrophy Type 1 Long read sequencing CRISPRi Brain Muscular dystrophy Acetylcholinesterase knockout mouse PCR Oligodendrocyte Genotype phenotype correlation Antisense oligonucleotide Maximal force Astrocyte Astrocytes Muscle Male Quantitative microdialysis Skeletal muscle Dystrophie myotonique ACETYLCHOLINESTERASE Alternative splicing ARN Fibrosis Diaphragm Dynamin 2