Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.

Emmanuelle Schmitt (1) , Marie Naveau (1) , Yves Mechulam (1)

1 BIOC - Laboratoire de Biochimie de l'Ecole polytechnique

Eukaryotic/archaeal translation initiation factor 2 (e/aIF2) is a heterotrimeric GTPase that plays a key role in selection of the correct start codon on messenger RNA. This review integrates structural and functional data to discuss the involvement of the three subunits in initiator tRNA binding. A possible role of the peripheral subunits in modulating the guanine nucleotide cycle on the core subunit is also addressed.

Domaines: Biochimie, Biologie Moléculaire

Emmanuelle Schmitt, Marie Naveau, Yves Mechulam. Eukaryotic and archaeal translation initiation factor 2: a heterotrimeric tRNA carrier.. FEBS Letters, 2010, 584 (2), pp.405-12. ⟨10.1016/j.febslet.2009.11.002⟩. ⟨hal-00498253⟩