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Synthesis of specific nanoparticles for targeting tumor angiogenesis using electron-beam irradiation
Abstract : Angiogenesis plays a critical role in both growth and metastasis of tumors. Vascular endothelial growth factor (VEGF) is an endogenous mediator of tumor angiogenesis. Blocking associations of the VEGF with its corresponding receptors (KDR) have become critical for anti-tumor therapy. Acyclo-peptide (CBO- P11), derived from VEGF, able to inhibit the interaction between the growth factor and its receptor, was synthesized in our laboratory to provide a target for angiogenesis. We have prepared biocompatible poly(vinylidenefluoride (PVDF) nanoparticles in order to obtain long blood circulating systems. Electron-beam (EB) irradiation was used to activate the PVDF nanoparticles. From electron paramagnetic resonance (EPR) measurements, we studied the radical stability in order to optimize the radio-grafting of acrylicacid (AA). Further functionalization of PVDF-g-PAA nanoparticles with the cyclo-peptide via a spacer arm was also possible by performing coupling reactions. High resolution magic angle spinning nuclear magnetic resonance (HRMAS NMR) and MALDI mass spectrometry allowed us to follow each chemical step of this peptide immobilization. We designed a new nanodevice suggesting a great potential for targeting angiogenesis.
Cited literature [17 references]
https://hal-polytechnique.archives-ouvertes.fr/hal-00501869
Contributor : Marie-Claude Clochard <>
Submitted on : Tuesday, July 13, 2010 - 3:14:36 PM
Last modification on : Friday, July 31, 2020 - 9:24:05 AM
Long-term archiving on: : Thursday, October 14, 2010 - 3:36:25 PM
Contributor : Marie-Claude Clochard <>
Submitted on : Tuesday, July 13, 2010 - 3:14:36 PM
Last modification on : Friday, July 31, 2020 - 9:24:05 AM
Long-term archiving on: : Thursday, October 14, 2010 - 3:36:25 PM
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