Ultrashort relativistic electron bunches and spatio-temporal radiation biology

Abstract : The intensive developments of terawatt Ti:Sa lasers permit to extend laser-plasma interactions into the relativistic regime, providing very-short electron or proton bunches. Experimental researches developed at the interface of laser physics and radiation biology, using the combination of sub-picosecond electron beams in the energy range 2-15 MeV with femtosecond near-IR optical pulses might conjecture the real-time investigation of penetrating radiation effects. A perfect synchronization between the particle beam (pump) and optical beam at 820 nm (probe) allows subpicosecond time resolution. This emerging domain involves high-energy radiation femtochemistry (HERF) for which the early spatial energy deposition is decisive for the prediction of cellular and tissular radiation damages. With vacuum-focused intensities of 2.7 x 10^19 W cm^-2 and a high energy electron total charge of 2.5 nC, radiation events have been investigated in the temporal range 10^-13 - 10^-10s. The early radiation effects of secondary electron on biomolecular sensors may be investigated inside sub-micrometric ionisation, considering the radial direction of Gaussian electron bunches. It is shown that short range electron-biosensor interactions lower than 10 A take place in nascent track structures triggered by penetrating radiation bunches. The very high dose delivery 10^13 Gy s^-1 performed with laser plasma accelerator may challenge our understanding of nanodosimetry on the time scale of molecular target motions. High-quality ultrashort penetrating radiation beams open promising opportunities for the development of spatio-temporal radiation biology, a crucial domain of cancer therapy, and would favor novating applications in nanomedicine such as highly-selective shortrange pro-drug activation.
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Submitted on : Thursday, March 10, 2011 - 3:01:24 PM
Last modification on : Wednesday, July 3, 2019 - 10:48:02 AM

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Yann Gauduel, Jérôme Faure, Victor Malka. Ultrashort relativistic electron bunches and spatio-temporal radiation biology. SPIE Proceedings Series, 2008, 7080, pp.708002/1-708002/14. ⟨10.1117/12.793733⟩. ⟨hal-00575561⟩

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