Translation Initiation

Yves Mechulam 1 Sylvain Blanquet 1 Emmanuelle Schmitt 1
1 BIOC - Laboratoire de Biochimie de l'Ecole polytechnique
Abstract : Selection of correct start codons on mRNAs is a key step required for faithful translation of the genetic message. Such a selection occurs in a complex process, during which a translation-competent ribosome assembles, eventually having in its P site a specialized tRNAMet base paired with the start codon on the mRNA. This chapter summarizes recent advances describing, at the molecular level, the successive steps involved in the process. In particular, structural analyses concerning complexes containing ribosomal subunits, as well as detailed kinetic studies, have shed new light on the sequence of events leading to initiation of protein synthesis in Bacteria
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https://hal-polytechnique.archives-ouvertes.fr/hal-00772018
Contributor : Denis Roura <>
Submitted on : Wednesday, January 9, 2013 - 5:31:28 PM
Last modification on : Wednesday, March 27, 2019 - 3:56:02 PM

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  • HAL Id : hal-00772018, version 1

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CNRS | X | X-BIOCH | PARISTECH | X-DEP-BIO

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Yves Mechulam, Sylvain Blanquet, Emmanuelle Schmitt. Translation Initiation. A. Böck, R. Curtiss III, J. B. Kaper, P. D. Karp, F. C. Neidhardt, J. M. Slauch, and C. L. Squires. EcoSal - Escherichia coli and Salmonella: Cellular and Molecular Biology, ASM Press, Chapter 4.2.2, 2011. ⟨hal-00772018⟩

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