New biological labels based on functionalized YVO4:Eu nanoparticles

Domitile Giaume 1 V. Buissette 1 K. Lahlil 1 Thierry Gacoin 1 Jean-Pierre Boilot 1 Didier Casanova 2 Emmanuel Beaurepaire 2 Martin-Pierre Sauviat 2 A. Mercuri 2 Antigoni Alexandrou 2
1 LPMC - Laboratoire de physique de la matière condensée
2 LOB - Laboratoire d'optique et biosciences
Abstract : Lanthanide-ion doped oxide (YVO4:Eu) nanoparticles were synthesized as aqueous colloids and functionalized by a bioactive silane shell to be used as fluorescent biological labels. Nanoparticles functionalized with guanidinium groups were able to act as artificial toxins which specifically target Na+ channels. They were individually detectable in live cardiac myocytes. Functionalized oxide nanoparticles appear as a new interesting tool, especially attractive for long-term single-molecule tracking due to their photo-stability and long luminescence lifetime. © 2005 Materials Research Society.
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Submitted on : Monday, July 15, 2013 - 3:28:32 PM
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Domitile Giaume, V. Buissette, K. Lahlil, Thierry Gacoin, Jean-Pierre Boilot, et al.. New biological labels based on functionalized YVO4:Eu nanoparticles. MRS Fall Meeting - Symposium AA - Nanoscale Materials Science in Biology and Medicine, Nov 2004, Boston, MA, United States. pp.AA6.2, ⟨10.1557/PROC-845-AA6.2⟩. ⟨hal-00844507⟩

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