New biological labels based on functionalized YVO4:Eu nanoparticles

Domitile Giaume (1) , V. Buissette (1) , K. Lahlil (1) , Thierry Gacoin (1) , Jean-Pierre Boilot (1) , Didier Casanova (2) , Emmanuel Beaurepaire (2) , Martin-Pierre Sauviat (2) , A. Mercuri (2) , Antigoni Alexandrou (2)

1 LPMC - Laboratoire de physique de la matière condensée
2 LOB - Laboratoire d'optique et biosciences

Lanthanide-ion doped oxide (YVO4:Eu) nanoparticles were synthesized as aqueous colloids and functionalized by a bioactive silane shell to be used as fluorescent biological labels. Nanoparticles functionalized with guanidinium groups were able to act as artificial toxins which specifically target Na+ channels. They were individually detectable in live cardiac myocytes. Functionalized oxide nanoparticles appear as a new interesting tool, especially attractive for long-term single-molecule tracking due to their photo-stability and long luminescence lifetime. © 2005 Materials Research Society.

Domitile Giaume, V. Buissette, K. Lahlil, Thierry Gacoin, Jean-Pierre Boilot, et al.. New biological labels based on functionalized YVO4:Eu nanoparticles. MRS Fall Meeting - Symposium AA - Nanoscale Materials Science in Biology and Medicine, Nov 2004, Boston, MA, United States. pp.AA6.2, ⟨10.1557/PROC-845-AA6.2⟩. ⟨hal-00844507⟩