Collision-induced dissociations of trimethylsilylated lysergic acid diethylamide (LSD) in ion trap multiple stage mass spectrometry

Abstract : The first part of this work was devoted to the determination of the most sensitive GC-MS2 method for LSD detection on the ion trap apparatus. On neat samples, it has been shown that trimethylsilylation of LSD decreases the detection threshold by a factor 10 and that chemical ionization using acetonitrile as the reagent gas provides a method seven times more sensitive than electron ionization. The decomposition pathways of protonated trimethylsilylated LSD were determined owing to isotopic labeling and MSn experiments with n up to 4. The ion trap analyzer allowed the observation of intermediate ions that are not observed in triple quadrupole analysis. The resort to MS3 and MS4 experiments also permitted to show evidence of isobaric daughter ions and to attribute the corresponding structures. © 2002 Elsevier Science B.V. All rights reserved.
Document type :
Journal articles
Complete list of metadatas

https://hal-polytechnique.archives-ouvertes.fr/hal-00918090
Contributor : Denis Roura <>
Submitted on : Friday, December 13, 2013 - 5:31:09 PM
Last modification on : Wednesday, March 20, 2019 - 12:12:02 PM

Identifiers

Collections

Citation

Danielle Libong, Stéphane Bouchonnet. Collision-induced dissociations of trimethylsilylated lysergic acid diethylamide (LSD) in ion trap multiple stage mass spectrometry. International Journal of Mass Spectrometry, Elsevier, 2002, 219 (3), pp.615-624. ⟨10.1016/S1387-3806(02)00746-7⟩. ⟨hal-00918090⟩

Share

Metrics

Record views

106