A Bottom-Up Approach to Build the Hyperpolarizability of Peptides and Proteins from their Amino-Acids

Julien Duboisset 1 Ariane Deniset-Besseau 2 Emmanuel Benichou 1 Isabelle Russier-Antoine 1 Noëlle Lascoux 1 Christian Jonin 1 François Hache 2 Marie-Claire Schanne-Klein 2 Pierre-Francois Brevet 1
1 ILM - Institut Lumière Matière [Villeurbanne]
2 LOB - Laboratoire d'optique et biosciences
Abstract : We experimentally demonstrate that some peptides and proteins lend themselves to an elementary analysis where their first hyperpolarizability can be decomposed into the coherent superposition of the first hyperpolarizability of their elementary units. We then show that those elementary units can be associated with the amino acids themselves in the case of nonaromatic amino acids and nonresonant second harmonic generation. As a case study, this work investigates the experimentally determined first hyperpolarizability of rat tail Type I collagen and compares it to that of the shorter peptide [(PPG)10]3, where P and G are the one-letter code for Proline and Glycine, respectively, and that of the triamino acid peptides PPG and GGG. An absolute value of (0.16 ± 0.01) × 10-30 esu for the first hyperpolarizability of nonaromatic amino acids is then obtained by using the newly defined 0.087 × 10-30 esu reference value for water. By using a collagen like model, the microscopic hyperpolarizability along the peptide bond can be evaluated at (0.7 ± 0.1) × 10-30 esu.
Document type :
Journal articles
Complete list of metadatas
https://hal-polytechnique.archives-ouvertes.fr/hal-00934822
Contributor : Denis Roura <>
Submitted on : Wednesday, January 22, 2014 - 4:06:46 PM
Last modification on : Thursday, February 7, 2019 - 4:04:07 PM

Identifiers

Collections

PARISTECH | X | X-LOB | UNIV-LYON1 | X-DEP-BIO

Citation

Julien Duboisset, Ariane Deniset-Besseau, Emmanuel Benichou, Isabelle Russier-Antoine, Noëlle Lascoux, et al.. A Bottom-Up Approach to Build the Hyperpolarizability of Peptides and Proteins from their Amino-Acids. Journal of Physical Chemistry B, American Chemical Society, 2013, 117 (34), pp.9877-9881. ⟨10.1021/jp312574q⟩. ⟨hal-00934822⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

137

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD