Metal-free aerobic oxidation of benzazole derivatives

Aurelie dos Santos (1) , Laurent El Kaim (1) , Laurence Grimaud (2)

1 DCSO - Laboratoire de synthèse organique
2 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)

2-Benzyl benzothiazoles and benzimidazoles are easily oxidized under air and basic conditions to give the corresponding ketones in good yields. The use of palladium acetate as a catalyst has little effect and even gives, in some cases, much lower yields.

Domains: Chemical Sciences

Aurelie dos Santos, Laurent El Kaim, Laurence Grimaud. Metal-free aerobic oxidation of benzazole derivatives. Organic & Biomolecular Chemistry, 2013, 11 (20), pp.3282-3287. ⟨10.1039/c3ob27404g⟩. ⟨hal-00949977⟩