Expedient approach to novel N-unprotected bicyclic azapyrimidine and pyridine structures.

Zhibo Liu (1) , Ling Qin (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

A direct route to novel bicyclic N-unprotected azapyrimidine structures including fused five-, six-, and seven-membered rings is described involving radical addition and cyclization of xanthates; this approach could be partially extended to pyridines.

Domains: Chemical Sciences; Organic chemistry

Zhibo Liu, Ling Qin, Samir Z. Zard. Expedient approach to novel N-unprotected bicyclic azapyrimidine and pyridine structures.. Organic Letters, 2012, 14 (23), pp.5976-5979. ⟨10.1021/ol3028829⟩. ⟨hal-00949984⟩