Ugi-Smiles couplings of 4-substituted pyridine derivatives: A fast access to chloroquine analogues

Laurent El Kaim (1) , Laurence Grimaud (1) , Patil Pravin (1)

1 DCSO - Laboratoire de synthèse organique

4-Hydroxy and mercapto pyridines were successfully tested in Ugi-Smiles couplings. Such multicomponent reactions applied to quinoline derivatives afford a very convenient and short synthesis of antimalarial analogues. © 2011 American Chemical Society.

Domaines: Chimie organique

Laurent El Kaim, Laurence Grimaud, Patil Pravin. Ugi-Smiles couplings of 4-substituted pyridine derivatives: A fast access to chloroquine analogues. Organic Letters, 2012, 14 (2), pp.476-478. ⟨10.1021/ol202974w⟩. ⟨hal-00949992⟩