Water-soluble chromophores with star-shaped oligomeric arms: synthesis, spectroscopic studies and first results in bio-imaging and cell death induction

Cyrille Monnereau (1) , Sophie Marotte (2, 3) , Pierre-Henri Lanoe (1) , Olivier Maury (1) , Patrice L. Baldeck (1, 4) , David Kreher (5) , Arnaud Favier (3) , Marie-Therese Charreyre (3) , Jacqueline Marvel (2) , Yann Leverrier (2) , Chantal Andraud (1)

1 LC - Laboratoire de Chimie - UMR5182
2 I2V - Immunité infection vaccination
3 Laboratoire Joliot Curie
4 LIPhy - Laboratoire Interdisciplinaire de Physique [Saint Martin d’Hères]
5 DCSO - Laboratoire de synthèse organique

A simple polymerisation strategy allows water solubilisation of chromophores for biophotonics, with good conservation of their fluorescence quantum-yield. Preliminary investigations show that the resulting objects are valuable candidates for photodynamic therapy and two-photon fluorescence imaging.

Domains: Chemical Sciences; Organic chemistry

Cyrille Monnereau, Sophie Marotte, Pierre-Henri Lanoe, Olivier Maury, Patrice L. Baldeck, et al.. Water-soluble chromophores with star-shaped oligomeric arms: synthesis, spectroscopic studies and first results in bio-imaging and cell death induction. New Journal of Chemistry, 2012, 36 (11), pp.2328-2333. ⟨10.1039/c2nj40407a⟩. ⟨hal-00950001⟩