Enantioselective synthesis of a taxol C ring

Cong Ma 1 Stéphanie Schiltz 1 J. Prunet 2
1 DCSO - Laboratoire de synthèse organique
2 School of Chemistry
Abstract : An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful. © 2011 Institute of Organic Chemistry and Biochemistry.
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Submitted on : Wednesday, February 26, 2014 - 9:47:14 AM
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Cong Ma, Stéphanie Schiltz, J. Prunet. Enantioselective synthesis of a taxol C ring. Collection of Czechoslovak Chemical Communications, Institute of Organic Chemistry & Biochemistry, 2011, 76 (12), pp.1579-1594. ⟨10.1135/cccc2011039⟩. ⟨hal-00950021⟩

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