Enantioselective synthesis of a taxol C ring

Abstract : An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful. © 2011 Institute of Organic Chemistry and Biochemistry.
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Cong Ma, Stéphanie Schiltz, J. Prunet. Enantioselective synthesis of a taxol C ring. Collection of Czechoslovak Chemical Communications, Institute of Organic Chemistry & Biochemistry, 2011, 76 (12), pp.1579-1594. ⟨10.1135/cccc2011039⟩. ⟨hal-00950021⟩

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