Enantioselective synthesis of a taxol C ring

Cong Ma (1) , Stéphanie Schiltz (1) , J. Prunet (2)

1 DCSO - Laboratoire de synthèse organique
2 School of Chemistry

An enantioselective synthesis of a C ring of taxol has been accomplished. The key step is an oxidative cleavage of a derivative of the Wieland-Miescher ketone. A first attempt of a Shapiro reaction modelling the coupling of the C ring with the A fragment of taxol was also successful. © 2011 Institute of Organic Chemistry and Biochemistry.

Domaines: Chimie organique

Cong Ma, Stéphanie Schiltz, J. Prunet. Enantioselective synthesis of a taxol C ring. Collection of Czechoslovak Chemical Communications, 2011, 76 (12), pp.1579-1594. ⟨10.1135/cccc2011039⟩. ⟨hal-00950021⟩