Fluoroazaindolines by an uncommon radical ipso-substitution of a C-F bond

Yann Laot 1 Laurent Petit 1 Ngoc Diem My Tran 1 Samir Zard 1
1 DCSO - Laboratoire de synthèse organique
Abstract : Trifluoroazaindoline derivatives are prepared using the first synthetically useful radical ipso-substitution of a fluorine atom. The initial procedure has been improved to allow the gram scale synthesis of these building blocks, which can be regioselectively substituted by nucleophiles under mild conditions to rapidly access a library of new molecules. Oxidation to the corresponding fluoroazaindole core has also been accomplished. © 2011 CSIRO.
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Submitted on : Wednesday, February 26, 2014 - 9:49:44 AM
Last modification on : Thursday, May 2, 2019 - 2:40:05 PM

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Yann Laot, Laurent Petit, Ngoc Diem My Tran, Samir Zard. Fluoroazaindolines by an uncommon radical ipso-substitution of a C-F bond. Australian Journal of Chemistry, CSIRO Publishing, 2011, 64 (4), pp.416-425. ⟨10.1071/ch10422⟩. ⟨hal-00950022⟩

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