Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles

Aurélie dos Santos (1, 2) , Laurent El Kaim (2, 1) , Laurence Grimaud (1, 2) , Caroline Ronsseray (1, 2)

1 DCSO - Laboratoire de synthèse organique
2 UCP - Unité de Chimie et Procédés

Pyrazolidinones were prepared in a two-step sequence starting from a-hydrazonocarboxylic acids. After a four-component Ugi coupling, the resulting hydrazone was engaged in a copper triggered [3 + 2] cycloaddition/aerobic oxidation cascade. © 2011 Santos et al; licensee Beilstein-Institut.

Domaines: Chimie organique

Aurélie dos Santos, Laurent El Kaim, Laurence Grimaud, Caroline Ronsseray. Ugi post-condensation copper-triggered oxidative cascade towards pyrazoles. Beilstein Journal of Organic Chemistry, 2011, 7, pp.1310-1314. ⟨10.3762/bjoc.7.153⟩. ⟨hal-00951236⟩