Unusual approach to branched 3-alkynylamides and to 1,5-dihydropyrrol-2- ones

Abstract : [Chemical equation presented] Rare carboxamide branched alkynes such as 11a can be readily obtained by reaction of the electrophilic 4-alkylidene isoxazolinones with isocycanides followed by nitrosative cleavage of the heterocyclic ring. N-lodosuccinimide induced ring closure in the presence of a nucleophile results in the formation of new iodopyrrolinones such as 16c. © 2010 American Chemical Society.
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Igor Dias-Jurberg, Fabien Gagosz, Samir Zard. Unusual approach to branched 3-alkynylamides and to 1,5-dihydropyrrol-2- ones. Organic Letters, American Chemical Society, 2010, 12 (3), pp.416-419. ⟨10.1021/ol902472r⟩. ⟨hal-00951257⟩

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