Unusual radical addition on a heteroaromatic nitrogen. A convenient access to new pyrimidine derivatives

Yann Laot (1) , Laurent Petit (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

A radical generated on the side-chain of a 2- or 4-N-alkylamino-4,6- or 2,6-dichloropyrimidine can cyclise on the nitrogen or on the carbon of the pyrimidine ring depending on its position and on whether an acetyl or a Boc group is present on the extra-nuclear nitrogen. © 2010 The Royal Society of Chemistry.

Yann Laot, Laurent Petit, Samir Z. Zard. Unusual radical addition on a heteroaromatic nitrogen. A convenient access to new pyrimidine derivatives. Chemical Communications, 2010, 46 (31), pp.5784-5786. ⟨10.1039/c0cc00533a⟩. ⟨hal-00951258⟩