A convergent radical-based route to biaryls

Béatrice Quiclet-Sire (1) , Guillaume Revol (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

A route to blaryl-3-carboxylate esters Involving a radical 1,2-aryl migration has been developed. This strategy hinges on the radical addition of xanthate 2 to olefin 1 causing a 1,2-aryl shift leading to a,ß- unsaturated ester 5, which Is then converted Into blaryl 10 by treatment with DBU under microwave heating © 2009 American Chemical Society.

Domaines: Chimie organique

Béatrice Quiclet-Sire, Guillaume Revol, Samir Z. Zard. A convergent radical-based route to biaryls. Organic Letters, 2009, 11 (13), pp.2832-2835. ⟨10.1021/ol9010294⟩. ⟨hal-00951259⟩