A versatile radical based approach to O-alkylated hydroxylamines and oximes

Abstract : O-Alkylhydroxylamines, often used for the preparation of bioconjugates, can be readily obtained by radical addition to suitable O-alkenylhydroxylamine derivatives. In the case of N-Boc-O-allylhydroxylamine, the addition is unexpectedly followed by elimination resulting in an overall allylation of the radical species. © 2008 Elsevier Ltd. All rights reserved.
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Béatrice Quiclet-Sire, Daniel Woollaston, Samir Zard. A versatile radical based approach to O-alkylated hydroxylamines and oximes. Tetrahedron, Elsevier, 2008, 64 (52), pp.11917-11924. ⟨10.1016/j.tet.2008.08.113⟩. ⟨hal-00951273⟩

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