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Journal articles
Synthesis of the tricyclic core of colchicine via a dienyne tandem ring-closing metathesis reaction
Abstract : The synthesis of the tricyclic framework of colchicine has been achieved using a tandem ring-closing metathesis reaction of dienynes as the key step. In this process, both seven-membered rings B and C were formed in one step. Oxidation of tertiary allylic alcohol derived from the tandem metathesis product furnished an intermediate in the total synthesis of colchicine. © 2007 American Chemical Society.
https://hal-polytechnique.archives-ouvertes.fr/hal-00951293
Contributor : Denis Roura <>
Submitted on : Monday, March 3, 2014 - 2:40:13 PM
Last modification on : Tuesday, March 17, 2020 - 3:24:46 AM
Contributor : Denis Roura <>
Submitted on : Monday, March 3, 2014 - 2:40:13 PM
Last modification on : Tuesday, March 17, 2020 - 3:24:46 AM