Synthesis of the tricyclic core of colchicine via a dienyne tandem ring-closing metathesis reaction

François-Didier Boyer; Issam Hanna

doi:10.1021/ol070708j

Journal articles

Synthesis of the tricyclic core of colchicine via a dienyne tandem ring-closing metathesis reaction

François-Didier Boyer ¹ Issam Hanna ^{2, *}

* Corresponding author

1 UCB - Chimie Biologique

2 DCSO - Laboratoire de synthèse organique

Abstract : The synthesis of the tricyclic framework of colchicine has been achieved using a tandem ring-closing metathesis reaction of dienynes as the key step. In this process, both seven-membered rings B and C were formed in one step. Oxidation of tertiary allylic alcohol derived from the tandem metathesis product furnished an intermediate in the total synthesis of colchicine. © 2007 American Chemical Society.

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Journal articles

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Chemical Sciences / Organic chemistry

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Synthesis of the tricyclic core of colchicine via a dienyne tandem ring-closing metathesis reaction

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Synthesis of the tricyclic core of colchicine via a dienyne tandem ring-closing metathesis reaction

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