Kalanchosine dimalate, an anti-inflammatory salt from Kalanchoe brasiliensis

Abstract : This report describes the isolation and characterization of kalanchosine dimalate (KMC), an anti-inflammatory salt from the fresh juice of the aerial parts of Kalanchoe brasiliensis. KMC comprises the new metabolite kalanchosine (1) and malic acid (2) in a 1:2 stoichiometric ratio. Kalanchosine (1), 3,6-diamino-4,5-dihydroxyoctanedioic acid, is the first naturally occurring dimeric bis(γ-hydroxy-β-amino acid) and is at least partially responsible for the anti-inflammatory properties of K. brasiliensis. © 2006 American Chemical Society and American Society of Pharmacognosy.
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Submitted on : Monday, March 24, 2014 - 8:57:06 PM
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S.S. Costa, M.D.L. Mendes de Souza, T. Ibrahim, G.O. de Melo, A.P. de Almeida, et al.. Kalanchosine dimalate, an anti-inflammatory salt from Kalanchoe brasiliensis. Journal of Natural Products, American Chemical Society, 2006, 69 (5), pp.815-818. ⟨10.1021/np050475+⟩. ⟨hal-00954775⟩

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