Radical additions of xanthates to vinyl epoxides and related derivatives: A powerful tool for the modular creation of quaternary centers

Nicolas Charrier (1) , David Gravestock (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

(Chemical Equation Presented) An open relationship: The triethylborane/O2-mediated addition of xanthates to vinyl epoxides and derivatives represents an efficient process to form carbon-carbon bonds. Complex structures can be rapidly assembled in a modular, convergent manner, under mild conditions, using readily available reagents (see scheme, Bn = benzyl). The formation of quaternary centers proved especially facile. © 2006 Wiley-VCH Verlag GmbH & Co. KGaA.

Domaines: Chimie organique

Nicolas Charrier, David Gravestock, Samir Z. Zard. Radical additions of xanthates to vinyl epoxides and related derivatives: A powerful tool for the modular creation of quaternary centers. Angewandte Chemie International Edition, 2006, 45 (39), pp.6520-6523. ⟨10.1002/anie.200601567⟩. ⟨hal-00954778⟩