A direct approach to a-trifluoromethylamines

Fabien Gagosz (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

(Matrix presented) S-[1-(N-Acetylamino)-2,2,2-trifluoroethyl]-O-ethyl dithiocarbonate (6), a readily available xanthate, adds efficiently to various functionalized olefins to give the corresponding adducts 8 via a radical chain reaction initiated by a small amount of lauroyl peroxide.

Domaines: Chimie organique

Fabien Gagosz, Samir Z. Zard. A direct approach to a-trifluoromethylamines. Organic Letters, 2003, 5 (15), pp.2655-2657. ⟨10.1021/ol034812m⟩. ⟨hal-00954822⟩