A flexible strategy for the divergent modification of pleuromutilin

E. Bacqué (1) , François Pautrat (2) , Samir Z. Zard (2)

1 Aventis
2 DCSO - Laboratoire de synthèse organique

The complex antibacterial natural product, pleuromutilin, can be directly modified by the radical addition reaction of various xanthates to the unactivated terminal olefin present on C-12.

Domaines: Chimie organique

E. Bacqué, François Pautrat, Samir Z. Zard. A flexible strategy for the divergent modification of pleuromutilin. Chemical Communications, 2002, - (20), pp.2312-2313. ⟨10.1039/B206568A⟩. ⟨hal-00954843⟩