A new convergent approach to α-branched alkynes

Delphine Renard (1) , Hadi Rezaei (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

A variety of a-branched alkynes can be easily assembled by a Knoevenagel type condensation of 4-unsubstituted isoxazolin-5-ones with aldehydes or ketones, followed by conjugate addition of an organometallic reagent and nitrosative cleavage of the heterocyclic ring.

Delphine Renard, Hadi Rezaei, Samir Z. Zard. A new convergent approach to α-branched alkynes. SYNLETT, 2002, 8, pp.1257-1260. ⟨10.1055/s-2002-32956⟩. ⟨hal-00954845⟩