Diastereoselective synthesis of protected syn 1,3-Diols: Preparation of the C16-C24 portion of dolabelides

L. Grimaud 1 R. de Mesmay 1 Joëlle Prunet 2
1 Laboratoire Chimie et Procédés
2 DCSO - Laboratoire de synthèse organique
Abstract : (Equation Presented) We have designed a new method to make synthons encompassing a protected syn 1,3-diol motif and an aldehyde a to the 1,3-dioxane ring. An additional stereocenter was also created, potentially leading to stereochemically defined 1,2,4-triols. This method was successfully applied to the synthesis of the C16-C24 portion of Dolabelides.
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Submitted on : Monday, March 17, 2014 - 9:42:42 PM
Last modification on : Thursday, February 7, 2019 - 5:17:28 PM

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L. Grimaud, R. de Mesmay, Joëlle Prunet. Diastereoselective synthesis of protected syn 1,3-Diols: Preparation of the C16-C24 portion of dolabelides. Organic Letters, American Chemical Society, 2002, 4 (3), pp.419-421. ⟨10.1021/ol017122w⟩. ⟨hal-00954856⟩

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