Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade

Edward Tate 1 Samir Zard 1
1 DCSO - Laboratoire de synthèse organique
Abstract : Routes to synthetic precursors of Lupin and Eburna alkaloids have been developed, featuring the rapid construction of highly functionalised intermediates by the intermolecular radical coupling of xanthates and alkenes, followed by acid-mediated condensation-cyclisation. © 2002 Elsevier Science Ltd. All rights reserved.
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Submitted on : Monday, March 17, 2014 - 9:36:52 PM
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Edward Tate, Samir Zard. Efficient construction of polycyclic alkaloid synthetic precursors by a xanthate free radical addition and Mannich cyclisation cascade. Tetrahedron Letters, Elsevier, 2002, 43 (26), pp.4683-4686. ⟨10.1016/s0040-4039(02)00835-3⟩. ⟨hal-00954857⟩

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