A new synthesis of 1-chloroalkynes

Sylvain Huppé (1) , Hadi Rezaei (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

4-Unsubstitued isoxazolinones derived from the corresponding ß-ketoesters can be chlorinated and converted into 1-chloroalkynes upon treatment with sodium nitrite and ferrous sulfate in aqueous acetic acid.

Domaines: Chimie organique

Sylvain Huppé, Hadi Rezaei, Samir Z. Zard. A new synthesis of 1-chloroalkynes. Chemical Communications, 2001, - (18), pp.1894-1895. ⟨10.1039/B106657A⟩. ⟨hal-00954869⟩