Microbiologically-assisted hemisynthesis of 1a-hydroxydrimenol

Gérard Aranda 1 M. Cortés 2 M. Maurs 3 R. Azerad 3
1 DCSO - Laboratoire de synthèse organique
2 UC - Pontificia Universidad Católica de Chile
3 LCBPT - UMR 8601 - Laboratoire de Chimie et de Biochimie Pharmacologiques et Toxicologiques
Abstract : The hemisynthesis of 1a-hydroxydrimenol has been selected to illustrate a synthetic route involving an initial microbial 3ß-hydroxylation of a drimenol derivative followed by a functionalization transfer to position 1a, thus generating a new potentially bioactive hydroxylated terpenic compound. Several methods have been investigated for the protection and the regeneration of the 7,8-double bond of drimenyl derivatives. © 2001 Elsevier Science Ltd. All rights reserved.
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Submitted on : Wednesday, March 12, 2014 - 9:49:48 PM
Last modification on : Tuesday, August 13, 2019 - 2:30:11 PM

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Gérard Aranda, M. Cortés, M. Maurs, R. Azerad. Microbiologically-assisted hemisynthesis of 1a-hydroxydrimenol. Tetrahedron: Asymmetry, Elsevier, 2001, 12 (14), pp.2013-2018. ⟨10.1016/s0957-4166(01)00353-6⟩. ⟨hal-00954877⟩

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