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Solid-phase synthesis of functionalized tropane derivatives via 1,3-dipolar cycloaddition
Abstract : 1,3-Dipolar cycloaddition of 3-oxidopyridinium betaine to activated olefins on solid-phase leads to resin-bound 8-azabicyclo[3.2.1]octenones which undergo further transformations such as 1,4-addition of nucleophiles. Cleavage of benzyl linker is achieved using acid chlorides in the presence of potassium iodide to give substituted tropane derivatives. © 2001 Elsevier Science Ltd.
https://hal-polytechnique.archives-ouvertes.fr/hal-00954879
Contributor : Denis Roura Connect in order to contact the contributor
Submitted on : Wednesday, March 12, 2014 - 9:41:54 PM
Last modification on : Thursday, March 5, 2020 - 6:25:48 PM
Contributor : Denis Roura Connect in order to contact the contributor
Submitted on : Wednesday, March 12, 2014 - 9:41:54 PM
Last modification on : Thursday, March 5, 2020 - 6:25:48 PM
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