Short cuts toward forskolin synthesis: A pentacyclic approach

Massoumé Leclaire (1) , Raymond Levet (1) , Franck Ferreira (1) , Paul-Henri Ducrot (2) , Jean-Yves Lallemand (3) , Louis Ricard (3)

1 DCSO - Laboratoire de synthèse organique
2 Unité de phytopharmacie et médiateurs chimiques
3 DCPH - Laboratoire Hétéroéléments et Coordination

A practical synthetic route for the preparation of forskolin intermediate 20 is described. Previously reported lactone 3 was converted to 20 through intermediate 16. The main feature of this work lies in the formation and the cleavage of a tetracyclic intermediate for the stereochemical control in the formation of the tricyclic core of forskolin.

Massoumé Leclaire, Raymond Levet, Franck Ferreira, Paul-Henri Ducrot, Jean-Yves Lallemand, et al.. Short cuts toward forskolin synthesis: A pentacyclic approach. Chemical Communications, 2000, 18, pp.1737-1738. ⟨10.1039/B004515M⟩. ⟨hal-00954908⟩