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Article Dans Une Revue Angewandte Chemie International Edition Année : 2000

Synthesis of highly functionalized cyclooctenes by ring-closing metathesis: Unexpected formation of a trans isomer

Résumé

Grubbs' and Schrock's catalysts can be used in ring-closing metathesis reactions (RCM) to synthesize highly functionalized cyclooctenes that have the required stereochemistry for the C1, C2, and C8 centers of taxol. The unprecedented formation of a trans isomer in the case of the carbonate derivative (see scheme) indicates that RCM does not always proceed to complete thermodynamic equilibrium.

Domaines

Chimie organique

Dates et versions

hal-00954912 , version 1 (06-03-2014)

Identifiants

Citer

Damien Bourgeois, A. Pancrazi, Louis Ricard, Joëlle Prunet. Synthesis of highly functionalized cyclooctenes by ring-closing metathesis: Unexpected formation of a trans isomer. Angewandte Chemie International Edition, 2000, 39 (4), pp.725-728. ⟨10.1002/(SICI)1521-3773(20000218)39:4<725::AID-ANIE725>3.0.CO;2-I⟩. ⟨hal-00954912⟩
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