Free-radical variant for the synthesis of functionalized 1,5-diketones.

Kelvin Kau Kiat Goh (1, 2) , Sunggak Kim (1) , Samir Z Zard (2)

1 Nanyang Technological University [Singapour]
2 DCSO - Laboratoire de synthèse organique

A free-radical approach for the synthesis of functionalized 1,5-diketones has been accomplished through an effective combination play between alkenylacylphosphonates and keto-xanthates as radical surrogates of enolates and enones, respectively.

Domains: Organic chemistry

Kelvin Kau Kiat Goh, Sunggak Kim, Samir Z Zard. Free-radical variant for the synthesis of functionalized 1,5-diketones.. Organic Letters, 2013, 15 (18), pp.4818-4821. ⟨10.1021/ol402213k⟩. ⟨hal-00966610⟩