Facile and Efficient One-Pot Synthesis of Highly Functionalized Thieno[2,3b]thiopyran-4-ones from b-Keto e-Xanthyl Phosphonates

Matthieu Corbet; Samir Zard

doi:10.1021/ol801033

Facile and Efficient One-Pot Synthesis of Highly Functionalized Thieno[2,3b]thiopyran-4-ones from b-Keto e-Xanthyl Phosphonates

Matthieu Corbet ¹ Samir Zard ¹

1 DCSO - Laboratoire de synthèse organique

Abstract : Synthesis of various functionalized thieno[2,3-b]thiopyran-4-ones from readily available β-keto ε-xanthyl phosphonates has been accomplished by combining a Horner−Wadsworth−Emmons olefination with a base-induced intramolecular domino cyclization/thio-Michael addition. The use of cyclic ketones in this transformation allowed a facile access to novel spiro-type thieno[2,3-b]thiopyran structures.

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Article dans une revue

Organic Letters, American Chemical Society, 2008, 10 (13), pp.2861-2864. 〈10.1021/ol801033〉

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Soumis le : lundi 31 mars 2014 - 21:22:07
Dernière modification le : jeudi 10 mai 2018 - 02:07:44

Facile and Efficient One-Pot Synthesis of Highly Functionalized Thieno[2,3b]thiopyran-4-ones from b-Keto e-Xanthyl Phosphonates

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Facile and Efficient One-Pot Synthesis of Highly Functionalized Thieno[2,3b]thiopyran-4-ones from b-Keto e-Xanthyl Phosphonates

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