Facile and Efficient One-Pot Synthesis of Highly Functionalized Thieno[2,3b]thiopyran-4-ones from b-Keto e-Xanthyl Phosphonates

Abstract : Synthesis of various functionalized thieno[2,3-b]thiopyran-4-ones from readily available β-keto ε-xanthyl phosphonates has been accomplished by combining a Horner−Wadsworth−Emmons olefination with a base-induced intramolecular domino cyclization/thio-Michael addition. The use of cyclic ketones in this transformation allowed a facile access to novel spiro-type thieno[2,3-b]thiopyran structures.
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Submitted on : Monday, March 31, 2014 - 9:22:07 PM
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Matthieu Corbet, Samir Zard. Facile and Efficient One-Pot Synthesis of Highly Functionalized Thieno[2,3b]thiopyran-4-ones from b-Keto e-Xanthyl Phosphonates. Organic Letters, American Chemical Society, 2008, 10 (13), pp.2861-2864. ⟨10.1021/ol801033⟩. ⟨hal-00968362⟩

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