Unified, radical-based approach for the synthesis of spiroketals.

Abstract : [reaction: see text] Functionalization of S-(3-chloro-2-oxo-propyl)-O-ethyl xanthate 1 by two consecutive xanthate transfer reactions, followed by spirocyclization of the resulting dihydroxy ketones, provides a flexible and highly convergent access to diversely substituted spiroketals, containing five-, six-, and seven-membered rings.
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Article dans une revue
Organic Letters, American Chemical Society, 2007, 9 (9), pp.1773-1776. 〈10.1021/ol070488+〉
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Soumis le : mercredi 2 avril 2014 - 10:32:42
Dernière modification le : jeudi 10 mai 2018 - 02:07:43

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Michiel De Greef, Samir Z. Zard. Unified, radical-based approach for the synthesis of spiroketals.. Organic Letters, American Chemical Society, 2007, 9 (9), pp.1773-1776. 〈10.1021/ol070488+〉. 〈hal-00969144〉

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