A concise synthesis of an advanced Clerodin intermediate through a Vaultier tandem reaction

Jean-Yves Lallemand (1, 2) , Yvan Six (1, 2) , Louis Ricard (3)

1 ICSN - Institut de Chimie des Substances Naturelles
2 DCSO - Laboratoire de synthèse organique
3 DCPH - Laboratoire Hétéroéléments et Coordination

A highly functionalised precursor of the antifeedant natural product Clerodin has been synthesised with good diastereocontrol. Key steps include a three-component version of the Vaultier tandem sequence, and an oxidative decarboxylation with a simple experimental procedure.

Jean-Yves Lallemand, Yvan Six, Louis Ricard. A concise synthesis of an advanced Clerodin intermediate through a Vaultier tandem reaction. European Journal of Organic Chemistry, 2002, 3, pp.503-513. ⟨10.1002/1099-0690(20022)2002:3<503::AID-EJOC503>3.0.CO;2-6⟩. ⟨hal-00969327⟩