Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins

Abstract : Dewetting is the spontaneous withdrawal of a liquid film from a non-wettable surface by nucleation and growth of dry patches. Two recent reports now propose that the principles of dewetting explain the physical phenomena underpinning the opening of transendothelial cell macroaperture (TEM) tunnels, referred to as cellular dewetting. This was discovered by studying a group of bacterial toxins endowed with the property of corrupting actomyosin cytoskeleton contractility. For both liquid and cellular dewetting, the growth of holes is governed by a competition between surface forces and line tension. We also discuss how the dynamics of TEM opening and closure represent remarkable systems to investigate actin cytoskeleton regulation by sensors of plasma membrane curvature and investigate the impact on membrane tension and the role of TEM in vascular dysfunctions.
Complete list of metadatas

https://hal-polytechnique.archives-ouvertes.fr/hal-00996493
Contributor : Denis Roura <>
Submitted on : Wednesday, May 28, 2014 - 2:37:34 PM
Last modification on : Wednesday, July 3, 2019 - 11:36:03 AM

Links full text

Identifiers

Citation

Emmanuel Lemichez, David Gonzalez-Rodriguez, Patricia Bassereau, Francoise Brochard-Wyart. Transcellular tunnel dynamics: Control of cellular dewetting by actomyosin contractility and I-BAR proteins. Biology of the Cell, Wiley, 2013, 105 (3), pp.109-117. ⟨10.1111/boc.201200063⟩. ⟨hal-00996493⟩

Share

Metrics

Record views

321