Soft Matter Models of Developing Tissues and Tumors

Abstract : Analogies with inert soft condensed matter-such as viscoelastic liquids, pastes, foams, emulsions, colloids, and polymers-can be used to investigate the mechanical response of soft biological tissues to forces. A variety of experimental techniques and biophysical models have exploited these analogies allowing the quantitative characterization of the mechanical properties of model tissues, such as surface tension, elasticity, and viscosity. The framework of soft matter has been successful in explaining a number of dynamical tissue behaviors observed in physiology and development, such as cell sorting, tissue spreading, or the escape of individual cells from a tumor. However, living tissues also exhibit active responses, such as rigidity sensing or cell pulsation, that are absent in inert soft materials. The soft matter models reviewed here have provided valuable insight in understanding morphogenesis and cancer invasion and have set bases for using tissue engineering within medicine.
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Science, American Association for the Advancement of Science, 2012, 338 (6109), pp.910-917. 〈10.1126/science.1226418〉
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Soumis le : mardi 27 mai 2014 - 17:35:10
Dernière modification le : vendredi 31 août 2018 - 09:18:24

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David Gonzalez-Rodriguez, Karine Guevorkian, Stephane Douezan, Francoise Brochard-Wyart. Soft Matter Models of Developing Tissues and Tumors. Science, American Association for the Advancement of Science, 2012, 338 (6109), pp.910-917. 〈10.1126/science.1226418〉. 〈hal-00996519〉

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