Comparative Study of the Folding/Unfolding Dynamics of Poly(glutamic acid) in Light and Heavy Water

Lucille Mendonça 1 Andreas Steinbacher 1 Raphaël Bouganne 1 François Hache 1, *
* Corresponding author
1 LOB - Laboratoire d'optique et biosciences
Abstract : The folding/unfolding equilibrium is investigated in poly(glutamic acid) (PGA) by two complementary sets of experiments: temperature-dependent steady-state circular dichroism spectra on the one hand and time-resolved circular dichroism measurements coupled with a T-jump experiment on the other hand. The experiments are performed for PGA dissolved in water for various pH values, as well as in heavy water. The kinetic and thermodynamic parameters extracted from these measurements are shown to be markedly different between light and heavy water, which is assigned to the difference in hydrogen bond energies in both solvents.
Document type :
Journal articles
Complete list of metadatas
https://hal-polytechnique.archives-ouvertes.fr/hal-01015311
Contributor : Denis Roura <>
Submitted on : Thursday, June 26, 2014 - 11:15:57 AM
Last modification on : Wednesday, November 13, 2019 - 3:54:03 PM

Identifiers

Collections

CNRS | X | X-LOB | PARISTECH | X-DEP-BIO

Citation

Lucille Mendonça, Andreas Steinbacher, Raphaël Bouganne, François Hache. Comparative Study of the Folding/Unfolding Dynamics of Poly(glutamic acid) in Light and Heavy Water. Journal of Physical Chemistry B, American Chemical Society, 2014, 118 (20), pp.5350-5356. ⟨10.1021/jp501282z⟩. ⟨hal-01015311⟩

Export

BibTeX TEI DC DCterms EndNote

Share

Metrics

Record views

203

Contact

Informations

CCSD