Carbon Radical Attack on a Pyrimidine Nitrogen. An Unusual Entry into Polycyclic Aminopyrimidones

Abstract : Unprecedented examples of a synthetically useful radical ring closure onto a pyrimidine nitrogen leading to novel, highly functionalized bi- and tricyclic pyrimidone structures are reported. An unexpected hydrogen atom translocation prior to the cyclization step was observed in some cases.
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Submitted on : Thursday, July 3, 2014 - 2:02:49 PM
Last modification on : Thursday, February 7, 2019 - 5:16:39 PM

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Ling Qin, Zhibo Liu, Samir Zard. Carbon Radical Attack on a Pyrimidine Nitrogen. An Unusual Entry into Polycyclic Aminopyrimidones. Organic Letters, American Chemical Society, 2014, 16 (11), pp.2966-2969. ⟨10.1021/ol501104h⟩. ⟨hal-01017929⟩

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