Carbon Radical Attack on a Pyrimidine Nitrogen. An Unusual Entry into Polycyclic Aminopyrimidones

Ling Qin (1) , Zhibo Liu (1) , Samir Z. Zard (1)

1 DCSO - Laboratoire de synthèse organique

Unprecedented examples of a synthetically useful radical ring closure onto a pyrimidine nitrogen leading to novel, highly functionalized bi- and tricyclic pyrimidone structures are reported. An unexpected hydrogen atom translocation prior to the cyclization step was observed in some cases.

Domains: Organic chemistry

Ling Qin, Zhibo Liu, Samir Z. Zard. Carbon Radical Attack on a Pyrimidine Nitrogen. An Unusual Entry into Polycyclic Aminopyrimidones. Organic Letters, 2014, 16 (11), pp.2966-2969. ⟨10.1021/ol501104h⟩. ⟨hal-01017929⟩