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Aspiration of biological viscoelastic drops

Abstract : Spherical cellular aggregates are in vitro systems to study the physical and biophysical properties of tissues. We present a novel approach to characterize the mechanical properties of cellular aggregates using a micropipette aspiration technique. We observe an aspiration in two distinct regimes: a fast elastic deformation followed by a viscous flow. We develop a model based on this viscoelastic behavior to deduce the surface tension, viscosity, and elastic modulus. A major result is the increase of the surface tension with the applied force, interpreted as an effect of cellular mechanosensing. © 2010 The American Physical Society.
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K. Guevorkian, M.-J. Colbert, Mélanie Durth, S. Dufour, F. Brochard-Wyart. Aspiration of biological viscoelastic drops. Physical Review Letters, 2010, 104 (May), pp.218101. ⟨10.1103/physrevlett.104.218101⟩. ⟨hal-01020626⟩



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