Nitrile Synthesis through Catalyzed Cascades Involving Acid-Nitrile Exchange

Damien Cartigny (1) , Aurélie dos Santos (2) , Laurent El Kaim (2) , Laurence Grimaud (3) , Roland Jacquot (4) , Philippe Marion (4)

1 E2P2L - Eco-Efficient Products & Processes Laboratory
2 DCSO - Laboratoire de synthèse organique
3 PASTEUR - Processus d'Activation Sélective par Transfert d'Energie Uni-électronique ou Radiatif (UMR 8640)
4 Solvay Recherches & Innovation Centre de Lyon

Irreversible acid-nitrile exchange reactions using both glutaronitrile and (phenylsulfonyl)acetonitrile may be catalyzed by Lewis acids. Whereas a cyclization towards imides displaces the equilibria in the reaction with dinitriles, a decarboxylation step is involved when using the (phenylsulfonyl)acetonitrile.

Domains: Chemical Sciences; Organic chemistry

Damien Cartigny, Aurélie dos Santos, Laurent El Kaim, Laurence Grimaud, Roland Jacquot, et al.. Nitrile Synthesis through Catalyzed Cascades Involving Acid-Nitrile Exchange. Synthesis: Journal of Synthetic Organic Chemistry, 2014, 46 (13), pp.1802-1806. ⟨10.1055/s-0033-1341227⟩. ⟨hal-01044733⟩