Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis

Abstract : An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.
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Submitted on : Thursday, July 24, 2014 - 10:19:13 AM
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Aurélien Letort, Rémi Aouzal, Cong Ma, Deliang Long, Joëlle Prunet. Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis. Organic Letters, American Chemical Society, 2014, 16 (12), pp.3300-3303. ⟨10.1021/ol501304j⟩. ⟨hal-01044768⟩

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