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Journal Articles Organic Letters Year : 2014

Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis

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Aurélien Letort
  • Function : Author
Deliang Long
  • Function : Author
Joëlle Prunet
  • Function : Correspondent author
  • PersonId : 958797

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Abstract

An efficient enantioselective synthesis of the ABC tricyclic core of the anticancer drug Taxol is reported. The key step of this synthesis is a cascade metathesis reaction, which leads in one operation to the required tricycle if appropriate fine-tuning of the dienyne precursor is performed.

Dates and versions

hal-01044768 , version 1 (24-07-2014)

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Aurélien Letort, Rémi Aouzal, Cong Ma, Deliang Long, Joëlle Prunet. Highly Efficient Synthesis of the Tricyclic Core of Taxol by Cascade Metathesis. Organic Letters, 2014, 16 (12), pp.3300-3303. ⟨10.1021/ol501304j⟩. ⟨hal-01044768⟩
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