Modeling Arterial Drug Transport from Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution close to the Endothelial Surface

Abstract : Drug-eluting stents (DES) are commonly used for treating coronary atherosclerosis. Despite the broad effectiveness of DES, ~5% of treated patients experience complications including in-stent restenosis and late-stent thrombosis. Furthermore, drugs used in DES not only inhibit proliferation of smooth muscle cells but also affect re-endothelialization. We have developed a computational model of the transport of drugs eluted from DES within stented arteries. Previous models have typically treated the arterial wall as one homogeneous porous medium and have often ignored drug reaction with cells in the arterial wall or used an equilibrium assumption. Our model incorporates the multi-layer structure of the arterial wall and accounts for the reaction of the eluted drug with cells of the arterial wall.
Type de document :
Communication dans un congrès
2011 COMSOL Conference, Oct 2011, Stuttgart, Germany. 2011
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https://hal-polytechnique.archives-ouvertes.fr/hal-01049398
Contributeur : Denis Roura <>
Soumis le : vendredi 25 juillet 2014 - 13:37:29
Dernière modification le : jeudi 10 mai 2018 - 02:03:23

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  • HAL Id : hal-01049398, version 1

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Franz Bozsak, Jean-Marc Chomaz, Abdul I. Barakat. Modeling Arterial Drug Transport from Drug-eluting Stents: Effect of Blood Flow on the Concentration Distribution close to the Endothelial Surface. 2011 COMSOL Conference, Oct 2011, Stuttgart, Germany. 2011. 〈hal-01049398〉

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