Ti(OiPr)(4)/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions

Abstract : A convenient method for the [2+2+2] cyclotrimerisation of alkynes using Ti(OiPr)4/nBuLi is presented. Homotrimerisation of arylacetylenes proceeds within minutes with excellent regioselectivity. Moreover, the intermolecular construction of ABB heterotrimers can be achieved selectively from two different alkynes with similar electronic properties. The method is also suitable for the synthesis of pyridines.
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Chemical Communications, Royal Society of Chemistry, 2014, 50 (may), pp.7666-7669. 〈10.1039/C4CC02698E〉
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https://hal-polytechnique.archives-ouvertes.fr/hal-01057803
Contributeur : Denis Roura <>
Soumis le : lundi 25 août 2014 - 14:19:33
Dernière modification le : jeudi 10 mai 2018 - 02:07:43

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Valentin Rassadin, E. Nicolas, Yvan Six. Ti(OiPr)(4)/nBuLi: an attractive reagent system for [2+2+2] cyclotrimerisation reactions. Chemical Communications, Royal Society of Chemistry, 2014, 50 (may), pp.7666-7669. 〈10.1039/C4CC02698E〉. 〈hal-01057803〉

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