Anticipating the fate and impact of organic environmental contaminants: a new approach applied to the pharmaceutical furosemide.

Céline Laurencé 1 Michael Rivard 1 Thierry Martens 1, * Christophe Morin 2 Didier Buisson 3 Sophie Bourcier 4 Michel Sablier 4, 5 Mehmet A. Oturan 6, *
* Corresponding author
1 ICMPE - Institut de Chimie et des Matériaux Paris-Est
2 CRRET - Laboratoire de recherche sur la croissance cellulaire, la réparation et la régénération tissulaires
3 MCAM - Molécules de Communication et Adaptation des Micro-Organismes
4 DCMR - Laboratoire des mécanismes réactionnels
5 CRCC - Centre de Recherche pour la Conservation des Collections
CRC - Centre de Recherche sur la Conservation
6 LGE - Laboratoire Géomatériaux et Environnement
Abstract : The presence of trace levels of organic contaminants in the environment is currently an environmental concern. When these contaminants are subjected to environmental transformations, environmental transformation products (ETPs) are obtained, whose structures often remain unknown. The absence of information concerning these new compounds makes them unavailable and consequently makes their environmental detection as well as their (eco)toxicological study impossible. This report describes a multidisciplinary approach that seeks to both anticipate the fate and evaluate the impact of organic environmental contaminants. Our approach consists of three steps. First, isolated and fully characterized transformation products (TPs) of the parent molecule are obtained. In the second step, the parent molecule is subjected to environmentally relevant transformations to identify plausible ETPs. The detection of previously characterized TPs allows the concomitant identification of plausible ETPs. The third step is devoted to the toxicological evaluation of the identified plausible ETPs. Such an approach has recently been applied to furosemide and has allowed the identification of its main TPs. This report now seeks to identify and evaluate toxicologically plausible ETPs of this drug, which is also known as an environmental contaminant.
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Journal articles
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Submitted on : Thursday, September 18, 2014 - 2:09:05 PM
Last modification on : Tuesday, April 2, 2019 - 3:05:07 AM

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LGE | UNIV-MLV | UPEC-UPEM | CV_LGE | PARISTECH | X | X-DCMR | INC-CNRS | CONSERVATION | X-DEP-CHIM | MNHN

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Céline Laurencé, Michael Rivard, Thierry Martens, Christophe Morin, Didier Buisson, et al.. Anticipating the fate and impact of organic environmental contaminants: a new approach applied to the pharmaceutical furosemide.. Chemosphere, Elsevier, 2014, 113, pp.193-199. 〈10.1016/j.chemosphere.2014.05.036〉. 〈hal-01065705〉

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